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Issue 10, 2010

Selenium-containing block copolymers and their oxidation-responsive aggregates

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Abstract

A selenium-containing amphiphilic block copolymer (PEG-PUSe-PEG) with a hydrophobic polyselenide block and two hydrophilic poly(ethylene glycol) (PEG) blocks was synthesized via polymerization of toluene diisocyanate (TDI) with monoselenide-containing diols and subsequent termination with PEG monomethylether. PEG-PUSe-PEG is able to self-assemble in aqueous solution to form block copolymer aggregates. Interestingly, it was found that the aggregates have a good oxidation-responsiveness and undergo a structural dissociation in a mild oxidative environment (such as 0.1% H2O2 v/v) due to the unique sensitivity of selenide groups in presence of oxidants. Compared with the sulfide analogue PEG-PUS-PEG, PEG-PUSe-PEG is more sensitive to oxidants. It is anticipated that selenium-containing block copolymer aggregates may find application in the field of drug delivery systems.

Graphical abstract: Selenium-containing block copolymers and their oxidation-responsive aggregates

Article information


Submitted
05 May 2010
Accepted
07 Jun 2010
First published
08 Jul 2010

Polym. Chem., 2010,1, 1609-1614
Article type
Paper

Selenium-containing block copolymers and their oxidation-responsive aggregates

N. Ma, Y. Li, H. Ren, H. Xu, Z. Li and X. Zhang, Polym. Chem., 2010, 1, 1609 DOI: 10.1039/C0PY00144A

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