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Issue 9, 2010
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Synthesis of glycopolymers and their multivalent recognitions with lectins

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Abstract

Synthetic carbohydrate ligands – also widely known as glycopolymers – are known to undergo numerous recognition events when interacting with their corresponding lectins. Interactions are greatly enhanced due to the multivalent character displayed by the large number of repeating carbohydrate units along the polymers (pendant glycopolymers); therefore, resulting what is called the “glycocluster effect”. Moreover, the strength and the availability of these multivalent recognitions can be tuned via the architecture of the glycopolymers. Hence, understanding the mechanistic interactions between the types of lectins (plant, animal, toxin and bacteria) with their synthetic ligands is crucial. This review focuses on the synthesis of pendant glycopolymers via various synthetic pathways (free radical polymerization, NMP, RAFT, ATRP, cyanoxyl mediated polymerization, ROP, ROMP and post-polymerization modification) and their interactions with their respectively lectins.

Graphical abstract: Synthesis of glycopolymers and their multivalent recognitions with lectins

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Publication details

The article was received on 11 Mar 2009, accepted on 04 May 2010 and first published on 30 Jun 2010


Article type: Review Article
DOI: 10.1039/C0PY00141D
Polym. Chem., 2010,1, 1392-1412

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    Synthesis of glycopolymers and their multivalent recognitions with lectins

    S. R. S. Ting, G. Chen and M. H. Stenzel, Polym. Chem., 2010, 1, 1392
    DOI: 10.1039/C0PY00141D

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