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Issue 24, 2010
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Mutanobactin A from the human oral pathogen Streptococcus mutans is a cross-kingdom regulator of the yeast-mycelium transition

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Abstract

The recent investigation of a gene cluster encoding for a hybrid PKS-NRPS metabolite in the oral pathogen Streptococcus mutans UA159 yielded evidence that this natural product might play an important role regulating a range of stress tolerance factors. We have now characterized the major compound generated from this gene cluster, mutanobactin A, and demonstrated that this secondary metabolite is also capable of influencing the yeast-mycelium transition of Candida albicans.

Graphical abstract: Mutanobactin A from the human oral pathogen Streptococcus mutans is a cross-kingdom regulator of the yeast-mycelium transition

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Publication details

The article was received on 13 Aug 2010, accepted on 06 Sep 2010 and first published on 20 Sep 2010


Article type: Communication
DOI: 10.1039/C0OB00579G
Org. Biomol. Chem., 2010,8, 5486-5489

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    Mutanobactin A from the human oral pathogen Streptococcus mutans is a cross-kingdom regulator of the yeast-mycelium transition

    P. M. Joyner, J. Liu, Z. Zhang, J. Merritt, F. Qi and R. H. Cichewicz, Org. Biomol. Chem., 2010, 8, 5486
    DOI: 10.1039/C0OB00579G

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