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Issue 20, 2010
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Straightforward synthesis of enantiopure (R)- and (S)-trifluoroalaninol

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Abstract

Two efficient routes are reported for the synthesis of both enantiomers of trifluoroalaninol in enantiopure form. The first pathway involves a Strecker-type reaction performed from a chiral trifluoromethyloxazolidine (Fox). The second route, which is more direct, involves, as a key step, the reduction of chiral oxazolidines or imines derived from ethyl trifluoropyruvate.

Graphical abstract: Straightforward synthesis of enantiopure (R)- and (S)-trifluoroalaninol

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Article information


Submitted
14 Jul 2010
Accepted
11 Aug 2010
First published
01 Sep 2010

Org. Biomol. Chem., 2010,8, 4540-4542
Article type
Communication

Straightforward synthesis of enantiopure (R)- and (S)-trifluoroalaninol

J. Pytkowicz, O. Stéphany, S. Marinkovic, S. Inagaki and T. Brigaud, Org. Biomol. Chem., 2010, 8, 4540
DOI: 10.1039/C0OB00424C

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