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Issue 17, 2010
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Chiral phosphine oxides in present-day organocatalysis

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The design and synthesis of new chiral Lewis bases is a field of extraordinary activity; in this context, while N-oxides derived from both N-heterocyclic systems and aliphatic amines have found widespread applications in organocatalysis, quite surprisingly phosphine oxides have been used less frequently. This contribution will highlight the relatively few examples of stereoselective transformations organocatalyzed by chiral phosphine oxides, discussing the different proposed reaction mechanisms and identifying topics for future investigation in what can be most certainly defined as an “Emerging Area”.

Graphical abstract: Chiral phosphine oxides in present-day organocatalysis

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Article information

26 Mar 2010
26 May 2010
First published
21 Jun 2010

Org. Biomol. Chem., 2010,8, 3824-3830
Article type
Emerging Area

Chiral phosphine oxides in present-day organocatalysis

M. Benaglia and S. Rossi, Org. Biomol. Chem., 2010, 8, 3824
DOI: 10.1039/C004681G

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