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Issue 12, 2010
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Small molecule-mediated inhibition of translation by targeting a native RNAG-quadruplex

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Abstract

Herein, we show that a naturally occurring RNA G-quadruplex element within the 5′ UTR of the human NRAS proto-oncogene is a target for a small molecule that inhibits translation in vitro. The present study provides a first demonstration that natural 5′ UTR mRNA G-quadruplexes have potential as molecular targets for small molecules that modulate translation.

Graphical abstract: Small molecule-mediated inhibition of translation by targeting a native RNA G-quadruplex

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Article information


Submitted
04 Feb 2010
Accepted
06 Apr 2010
First published
30 Apr 2010

Org. Biomol. Chem., 2010,8, 2771-2776
Article type
Paper

Small molecule-mediated inhibition of translation by targeting a native RNA G-quadruplex

A. Bugaut, R. Rodriguez, S. Kumari, S. D. Hsu and S. Balasubramanian, Org. Biomol. Chem., 2010, 8, 2771
DOI: 10.1039/C002418J

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