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Issue 12, 2010
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Small molecule-mediated inhibition of translation by targeting a native RNA G-quadruplex

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Abstract

Herein, we show that a naturally occurring RNA G-quadruplex element within the 5′ UTR of the human NRAS proto-oncogene is a target for a small molecule that inhibits translation in vitro. The present study provides a first demonstration that natural 5′ UTR mRNA G-quadruplexes have potential as molecular targets for small molecules that modulate translation.

Graphical abstract: Small molecule-mediated inhibition of translation by targeting a native RNA G-quadruplex

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Publication details

The article was received on 04 Feb 2010, accepted on 06 Apr 2010 and first published on 30 Apr 2010


Article type: Paper
DOI: 10.1039/C002418J
Citation: Org. Biomol. Chem., 2010,8, 2771-2776

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    Small molecule-mediated inhibition of translation by targeting a native RNA G-quadruplex

    A. Bugaut, R. Rodriguez, S. Kumari, S. D. Hsu and S. Balasubramanian, Org. Biomol. Chem., 2010, 8, 2771
    DOI: 10.1039/C002418J

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