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Issue 8, 2010
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The use of click chemistry in the emerging field of catalomics

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Abstract

Of the thousands of known chemical reactions, a handful of reactions, called “click” reactions, stand out with features such as good chemoselectivity, good solvent compatibilities, modularity, minimum synthetic demands, bioorthogonality and high yields. Among them, the Cu(I)-catalyzed 1,3-dipolar cycloaddition reaction between azides and terminal alkynes has emerged as a powerful tool in chemical biology and proteomics. This perspective surveys the significant contributions of click chemistry in catalomics (a sub-area in chemical proteomics), with special emphasis on activity-based protein profiling (ABPP), posttranslational modifications (PTMs) and enzyme inhibitor developments.

Graphical abstract: The use of click chemistry in the emerging field of catalomics

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Publication details

The article was received on 06 Nov 2009 and first published on 11 Feb 2010


Article type: Perspective
DOI: 10.1039/B923331H
Org. Biomol. Chem., 2010,8, 1749-1762

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    The use of click chemistry in the emerging field of catalomics

    K. A. Kalesh, H. Shi, J. Ge and S. Q. Yao, Org. Biomol. Chem., 2010, 8, 1749
    DOI: 10.1039/B923331H

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