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Issue 4, 2010
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A novel pseudo four component reaction involving homoenolate for the synthesis of γ-aminobutyric acid (GABA) derivatives

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Abstract

Homoenolate generated from α,β-unsaturated aldehydes by NHC catalysis underwent facile addition to conjugated sulfonimines, generated in situ, and subsequent methanolysis to afford protected GABA derivatives stereoselectively and in high yields, thus constituting a novel pseudo four component reaction.

Graphical abstract: A novel pseudo four component reaction involving homoenolate for the synthesis of γ-aminobutyric acid (GABA) derivatives

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Publication details

The article was received on 21 Jul 2009, accepted on 17 Dec 2009 and first published on 06 Jan 2010


Article type: Communication
DOI: 10.1039/B922981G
Org. Biomol. Chem., 2010,8, 761-764

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    A novel pseudo four component reaction involving homoenolate for the synthesis of γ-aminobutyric acid (GABA) derivatives

    V. Nair, V. Varghese, B. P. Babu, C. R. Sinu and E. Suresh, Org. Biomol. Chem., 2010, 8, 761
    DOI: 10.1039/B922981G

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