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Issue 5, 2010
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BVMO-catalysed dynamic kinetic resolution of racemic benzyl ketones in the presence of anion exchange resins

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Abstract

4-Hydroxyacetophenone monooxygenase from Pseudomonas fluorescens ACB was employed in the presence of a weak anion exchange resin to perform dynamic kinetic resolutions of racemic benzyl ketones with high conversions and good optical purities. Different parameters that affect to the efficiency of the enzymatic Baeyer–Villiger oxidation and racemisation were analyzed in order to optimize the activity and selectivity of the biocatalytic system.

Graphical abstract: BVMO-catalysed dynamic kinetic resolution of racemic benzyl ketones in the presence of anion exchange resins

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Article information


Submitted
30 Oct 2009
Accepted
30 Nov 2009
First published
07 Jan 2010

Org. Biomol. Chem., 2010,8, 1121-1125
Article type
Paper

BVMO-catalysed dynamic kinetic resolution of racemic benzyl ketones in the presence of anion exchange resins

C. Rodríguez, G. de Gonzalo, A. Rioz-Martínez, D. E. Torres Pazmiño, M. W. Fraaije and V. Gotor, Org. Biomol. Chem., 2010, 8, 1121
DOI: 10.1039/B922693A

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