Jump to main content
Jump to site search
Access to RSC content Close the message box

Continue to access RSC content when you are not at your institution. Follow our step-by-step guide.


Issue 9, 2010
Previous Article Next Article

ω-Transaminases as efficient biocatalysts to obtain novel chiral selenium-amine ligands for Pd-catalysis

Author affiliations

Abstract

ω-Transaminases have been evaluated as biocatalysts in the reductive amination of organoselenium acetophenones to the corresponding amines, and in the kinetic resolution of racemic organoselenium amines. Kinetic resolution proved to be more efficient than the asymmetric reductive amination. By using these methodologies we were able to obtain both amine enantiomers in high enantiomeric excess (up to 99%). Derivatives of the obtained optically pure o-selenium 1-phenylethyl amine were evaluated as ligands in the palladium-catalyzed asymmetric alkylation, giving the alkylated product in up to 99% ee.

Graphical abstract: ω-Transaminases as efficient biocatalysts to obtain novel chiral selenium-amine ligands for Pd-catalysis

Back to tab navigation

Supplementary files

Article information


Submitted
06 Oct 2009
Accepted
01 Feb 2010
First published
03 Mar 2010

Org. Biomol. Chem., 2010,8, 2043-2051
Article type
Paper

ω-Transaminases as efficient biocatalysts to obtain novel chiral selenium-amine ligands for Pd-catalysis

L. H. Andrade, A. V. Silva, P. Milani, D. Koszelewski and W. Kroutil, Org. Biomol. Chem., 2010, 8, 2043
DOI: 10.1039/B920946H

Social activity

Search articles by author

Spotlight

Advertisements