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Issue 20, 2010
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Asymmetric synthesis of chiral cyclic amine from cyclic imine by bacterial whole-cell catalyst of enantioselective imine reductase

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Abstract

Streptomyces sp. GF3587 and 3546 were found to be imine-reducing strains with high R- and S-selectivity by screening using 2-methyl-1-pyrroline (2-MPN). Their whole-cell catalysts produced 91 mM R-2-methylpyrrolidine (R-2-MP) with 99.2%e.e. and 27.5 mM S-2-MP (92.3%e.e.) from 2-MPN at 91–92% conversion in the presence of glucose, respectively.

Graphical abstract: Asymmetric synthesis of chiral cyclic amine from cyclic imine by bacterial whole-cell catalyst of enantioselective imine reductase

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Supplementary files

Article information


Submitted
30 Jun 2010
Accepted
12 Aug 2010
First published
12 Aug 2010

Org. Biomol. Chem., 2010,8, 4533-4535
Article type
Communication

Asymmetric synthesis of chiral cyclic amine from cyclic imine by bacterial whole-cell catalyst of enantioselective imine reductase

K. Mitsukura, M. Suzuki, K. Tada, T. Yoshida and T. Nagasawa, Org. Biomol. Chem., 2010, 8, 4533
DOI: 10.1039/C0OB00353K

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