Issue 4, 2010
From the journal:

Organic & Biomolecular Chemistry

Steroid hormones controlling the life cycle of the nematode Caenorhabditis elegans: stereoselective synthesis and biology

René Martin,a   Eugeni V. Entchev,b   Teymuras V. Kurzchaliab  and  Hans-Joachim Knölker*a  

* Corresponding authors

a Department Chemie, Technische Universität Dresden, Bergstrasse 66, 01069 Dresden, Germany
E-mail: hans-joachim.knoelker@tu-dresden.de
Fax: +49 351-463-37030

b Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, 01307 Dresden, Germany

Abstract

Cholesterol-derived hormones, the dafachronic acids, play a major role in controlling the life cycle and initiating dauer larva formation of the nematode Caenorhabditis elegans. This Perspective describes recent progress in the synthesis of these steroid hormones and their biological function.

Graphical abstract: Steroid hormones controlling the life cycle of the nematode Caenorhabditis elegans: stereoselective synthesis and biology

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Article information

DOI
https://doi.org/10.1039/B918488K
Article type
Perspective
Submitted
08 Sep 2009
Accepted
26 Oct 2009
First published
03 Dec 2009

Org. Biomol. Chem., 2010,8, 739-750

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Steroid hormones controlling the life cycle of the nematode Caenorhabditis elegans: stereoselective synthesis and biology

R. Martin, E. V. Entchev, T. V. Kurzchalia and H. Knölker, Org. Biomol. Chem., 2010, 8, 739 DOI: 10.1039/B918488K

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