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Issue 12, 2010
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Synthesis of core-shell gold coated magnetic nanoparticles and their interaction with thiolated DNA

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Abstract

Core-shell magnetic nanoparticles have received significant attention recently and are actively investigated owing to their large potential for a variety of applications. Here, the synthesis and characterization of bimetallic nanoparticles containing a magnetic core and a gold shell are discussed. The gold shell facilitates, for example, the conjugation of thiolated biological molecules to the surface of the nanoparticles. The composite nanoparticles were produced by the reduction of a gold salt on the surface of pre-formed cobalt or magnetite nanoparticles. The synthesized nanoparticles were characterized using ultraviolet-visible absorption spectroscopy, transmission electron microscopy, energy dispersion X-ray spectroscopy, X-ray diffraction and super-conducting quantum interference device magnetometry. The spectrographic data revealed the simultaneous presence of cobalt and gold in 5.6 ± 0.8 nm alloy nanoparticles, and demonstrated the presence of distinct magnetite and gold phases in 9.2 ± 1.3 nm core-shell magnetic nanoparticles. The cobalt-gold nanoparticles were of similar size to the cobalt seed, while the magnetite-gold nanoparticles were significantly larger than the magnetic seeds, indicating that different processes are responsible for the addition of the gold shell. The effect on the magnetic properties by adding a layer of gold to the cobalt and magnetite nanoparticles was studied. The functionalization of the magnetic nanoparticles is demonstrated through the conjugation of thiolated DNA to the gold shell.

Graphical abstract: Synthesis of core-shell gold coated magnetic nanoparticles and their interaction with thiolated DNA

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Supplementary files

Article information


Submitted
24 Aug 2010
Accepted
17 Sep 2010
First published
21 Oct 2010

Nanoscale, 2010,2, 2624-2630
Article type
Paper

Synthesis of core-shell gold coated magnetic nanoparticles and their interaction with thiolated DNA

I. Robinson, L. D. Tung, S. Maenosono, C. Wälti and N. T. K. Thanh, Nanoscale, 2010, 2, 2624
DOI: 10.1039/C0NR00621A

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