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Issue 5, 2010
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Chemistry and biology of siderophores

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Abstract

Covering: 1950 up to the end of 2009

Siderophores are compounds produced by bacteria, fungi and graminaceous plants for scavenging iron from the environment. They are low-molecular-weight compounds (500–1500 daltons) possessing a high affinity for iron(III) (Kf > 1030), the biosynthesis of which is regulated by iron levels and the function of which is to supply iron to the cell. This article briefly describes the classification and chemical properties of siderophores, before outlining research on siderophore biosynthesis and transport. Clinically important siderophores and the therapeutic potential of siderophore design are described. Appendix 1 provides a comprehensive list of siderophore structures.

Graphical abstract: Chemistry and biology of siderophores

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Submitted
26 Nov 2009
First published
07 Apr 2010

Nat. Prod. Rep., 2010,27, 637-657
Article type
Review Article

Chemistry and biology of siderophores

R. C. Hider and X. Kong, Nat. Prod. Rep., 2010, 27, 637
DOI: 10.1039/B906679A

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