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Issue 7, 2010
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Natural product mode of action (MOA) studies: a link between natural and synthetic worlds

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Abstract

Covering: 1st January 1998 to 1st July 2009, inclusive

In our understanding of matter, natural products deliver plots that would stun even the best productions of the legendary filmmaker, Sergio Leone. While every decade heralds a new genre of film (as well as avenues of small-molecule discovery), natural products and their “untamed prehistoric” plots continue to dazzle the fields of biotechnology, drug discovery, fragrances, food additives and agrochemistry. This review provides an abridged synopsis of the modes of natural product action discovered within the last decade and the tools and methods used in their discovery. Their stories are united in a common theme that unveils one of the more vital aspects of chemical biological research: understanding the global activity of Nature’s arsenal of secondary metabolites.

Graphical abstract: Natural product mode of action (MOA) studies: a link between natural and synthetic worlds

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Article information


Submitted
10 Sep 2009
First published
26 Apr 2010

Nat. Prod. Rep., 2010,27, 969-995
Article type
Review Article

Natural product mode of action (MOA) studies: a link between natural and synthetic worlds

J. J. La Clair, Nat. Prod. Rep., 2010, 27, 969
DOI: 10.1039/B909989C

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