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Issue 10, 2010

Metal-coordination-mediated sequential chelation-enhanced fluorescence (CHEF) and fluorescence resonance energy transfer (FRET) in a heteroditopic ligand system

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Abstract

Sequential fluorescence enhancement and fluorescence resonance energy transfer over a zinc ion gradient have been engineered in a two-fluorophore heteroditopic ligand platform. This is the first report that the strategies of metal-coordination modulated photoinduced electron transfer (PET), internal charge transfer (ICT), and fluorescence resonance energy transfer (FRET) are integrated in one synthetic fluoroionophore. Comparing to the previously reported single-fluorophore heteroditopic ligands (L. Zhang, R. J. Clark and L. Zhu, Chem. Eur. J. 2008, 14, 2894–2903), the resolution of two emission channels is greatly enhanced to almost 100 nm. This two-fluorophore heteroditopic platform lends promise to creating dual-emission fluorescent indicators where low- and high-target concentration regimes could be analyzed using independent emission filter sets.

Graphical abstract: Metal-coordination-mediated sequential chelation-enhanced fluorescence (CHEF) and fluorescence resonance energy transfer (FRET) in a heteroditopic ligand system

Supplementary files

Article information


Submitted
31 Mar 2010
Accepted
04 May 2010
First published
11 Jun 2010

New J. Chem., 2010,34, 2176-2182
Article type
Paper

Metal-coordination-mediated sequential chelation-enhanced fluorescence (CHEF) and fluorescence resonance energy transfer (FRET) in a heteroditopic ligand system

R. J. Wandell, A. H. Younes and L. Zhu, New J. Chem., 2010, 34, 2176 DOI: 10.1039/C0NJ00241K

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