Issue 5, 2010

Concise synthesis of novel acyclic analogues of cADPR with an ether chain as the northern moiety

Abstract

To study the properties of hydrolysates of cyclic adenosine diphosphate ribose (cADPR), a series of novel acyclic analogues of cADPR with an ether chain as the northern moiety and 8-substituted adenine or hypoxanthine as the base moiety were synthesized via an N1 substitution construction, followed by bisphosphorylation, phosphoramidition or pyrophosphorylation. These compounds also provide various precursors for synthesizing cADPR analogues.

Graphical abstract: Concise synthesis of novel acyclic analogues of cADPR with an ether chain as the northern moiety

Article information

Article type
Paper
Submitted
25 Oct 2009
Accepted
08 Dec 2009
First published
05 Feb 2010

New J. Chem., 2010,34, 956-966

Concise synthesis of novel acyclic analogues of cADPR with an ether chain as the northern moiety

H. Wu, Z. Yang, L. Zhang and L. Zhang, New J. Chem., 2010, 34, 956 DOI: 10.1039/B9NJ00595A

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