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Issue 3, 2010
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Cationic side-chains control DNA/RNA binding properties and antiproliferative activity of dicationic dibenzotetraaza[14]annulene derivatives

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Abstract

Studied dicationic dibenzotetraaza[14]annulene derivatives intercalate into synthetic double stranded DNA and RNA, while their positively charged side-chains additionally interact within the minor groove of polynucleotides, contributing to the overall affinity of compounds and controlling pronounced A–T(U) over G–C sequence preference as well as stronger thermal stabilization of ds-DNA than ds-RNA. Furthermore, all compounds showed moderate to high antiproliferative activity against five human tumour cell lines, whereby clear correlation between the structure of the side-chain and cytotoxic activity was observed.

Graphical abstract: Cationic side-chains control DNA/RNA binding properties and antiproliferative activity of dicationic dibenzotetraaza[14]annulene derivatives

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Publication details

The article was received on 17 Sep 2009, accepted on 23 Nov 2009 and first published on 15 Jan 2010


Article type: Paper
DOI: 10.1039/B9NJ00490D
New J. Chem., 2010,34, 500-507

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    Cationic side-chains control DNA/RNA binding properties and antiproliferative activity of dicationic dibenzotetraaza[14]annulene derivatives

    M. R. Stojković, M. Marjanović, D. Pawlica, L. Dudek, J. Eilmes, M. Kralj and I. Piantanida, New J. Chem., 2010, 34, 500
    DOI: 10.1039/B9NJ00490D

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