Issue 4, 2010
From the journal:

New Journal of Chemistry

A charge transfer type pH responsive fluorescent probe and its intracellular application†

Zhipeng Liu,ab   Changli Zhang,ad   Weijiang He,*a   Fang Qian,a   Xiaoliang Yang,a   Xiang Gaoc  and  Zijian Guo*ab  

* Corresponding authors

a State Key Laboratory of Coordination Chemistry, Coordination Chemistry Institute, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210093, P. R. China
E-mail: heweij69@nju.edu.cn, zguo@nju.edu.cn
Fax: +86 25 83314502
Tel: +86 25 83597066,+86 2583686218

b State Key Laboratory of Bioelectronics, Southeast University, Nanjing 210096, P. R. China

c Animal Model Research Center, Nanjing University, Nanjing 210093, P. R. China

d Nanjing Xiaozhuang College, Nanjing 210017, P. R. China

Abstract

A new charge transfer pH fluorescent probe BTP has been prepared by the ethylene bridging of benzothiazole and pyridine. The probe exhibits a specific fluorescent response to pH with a large Stokes shift, and the pH-induced emission enhancement factor (EEF) is about 22-fold when the pH is increased from 3.2 to 5.2. The presence of metal cations such as Na+, K+, Ca2+, Mg2+ and other transition metal cations does not interfere with its fluorescent pH response. In addition, the intracellular pH fluorescent imaging ability of the probe has been confirmed on macrophage cells using a confocal microscope.

Graphical abstract: A charge transfer type pH responsive fluorescent probe and its intracellular application

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Article information

DOI
https://doi.org/10.1039/B9NJ00703B
Article type
Paper
Submitted
24 Nov 2009
Accepted
25 Nov 2009
First published
04 Feb 2010

New J. Chem., 2010,34, 656-660

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A charge transfer type pH responsive fluorescent probe and its intracellular application

Z. Liu, C. Zhang, W. He, F. Qian, X. Yang, X. Gao and Z. Guo, New J. Chem., 2010, 34, 656 DOI: 10.1039/B9NJ00703B

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