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Issue 3, 2010
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Synthesis and biological evaluation of substituted α- and β-2,3-dihydrofuran naphthoquinones as potent anticandidal agents

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Abstract

We report herein, the synthesis and antifungal activity of substituted α- and β-dihydrofuran naphthoquinones. These compounds were prepared from readily available lawsone and olefins in the presence of cerium(IV) ammonium nitrate (CAN) and were then evaluated against the following six strains of Candida (C.): C. albicans, C. krusei, C. parapsilosis, C. kefyr, C. tropicalis and C. dubliniensis. In addition to exhibiting low cytotoxicity, the furan naphthoquinones proved to be active against these fungi, indicating that they are important scaffolds and potential novel antifungal agents.

Graphical abstract: Synthesis and biological evaluation of substituted α- and β-2,3-dihydrofuran naphthoquinones as potent anticandidal agents

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Supplementary files

Article information


Submitted
07 Jun 2010
Accepted
08 Jul 2010
First published
04 Aug 2010

Med. Chem. Commun., 2010,1, 229-232
Article type
Concise Article

Synthesis and biological evaluation of substituted α- and β-2,3-dihydrofuran naphthoquinones as potent anticandidal agents

C. P. V. Freire, S. B. Ferreira, N. S. M. de Oliveira, A. B. J. Matsuura, I. L. Gama, F. D. C. da Silva, M. C. B. V. de Souza, E. S. Lima and V. F. Ferreira, Med. Chem. Commun., 2010, 1, 229
DOI: 10.1039/C0MD00074D

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