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Issue 12, 2010
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Multi-enzyme logic network architectures for assessing injuries: digital processing of biomarkers

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Abstract

A multi-enzyme biocatalytic cascade processing simultaneously five biomarkers characteristic of traumatic brain injury (TBI) and soft tissue injury (STI) was developed. The system operates as a digital biosensor based on concerted function of 8 Boolean AND logic gates, resulting in the decision about the physiological conditions based on the logic analysis of complex patterns of the biomarkers. The system represents the first example of a multi-step/multi-enzyme biosensor with the built-in logic for the analysis of complex combinations of biochemical inputs. The approach is based on recent advances in enzyme-based biocomputing systems and the present paper demonstrates the potential applicability of biocomputing for developing novel digital biosensor networks.

Graphical abstract: Multi-enzyme logic network architectures for assessing injuries: digital processing of biomarkers

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Article information


Submitted
11 Aug 2010
Accepted
22 Sep 2010
First published
18 Oct 2010

Mol. BioSyst., 2010,6, 2554-2560
Article type
Paper

Multi-enzyme logic network architectures for assessing injuries: digital processing of biomarkers

J. Halámek, V. Bocharova, S. Chinnapareddy, J. R. Windmiller, G. Strack, M. Chuang, J. Zhou, P. Santhosh, G. V. Ramirez, M. A. Arugula, J. Wang and E. Katz, Mol. BioSyst., 2010, 6, 2554 DOI: 10.1039/C0MB00153H

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