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Issue 17, 2010
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Laboratory-scale protein striping system for patterning biomolecules onto paper-based immunochromatographic test strips

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Abstract

A method for patterning narrow lines of biomolecules onto nitrocellulose membranes using laboratory syringe pumps is described. One syringe pump is used to drive the biomolecule solution through a needle, while another modified syringe pump acts as a one-dimensional translation stage, moving the needle across the membrane much like a pen. This method consumes very small volumes of reagents, and is a viable option for laboratory-scale fabrication and prototyping of point-of-care rapid diagnostic test strips.

Graphical abstract: Laboratory-scale protein striping system for patterning biomolecules onto paper-based immunochromatographic test strips

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Article information


Submitted
12 Apr 2010
Accepted
11 Jun 2010
First published
06 Jul 2010

Lab Chip, 2010,10, 2279-2282
Article type
Technical Note

Laboratory-scale protein striping system for patterning biomolecules onto paper-based immunochromatographic test strips

M. A. Nash, J. M. Hoffman, D. Y. Stevens, A. S. Hoffman, P. S. Stayton and P. Yager, Lab Chip, 2010, 10, 2279
DOI: 10.1039/C004991C

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