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Issue 7, 2010
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Deformability considerations in filtration of biological cells

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Abstract

Biological cells are highly sensitive to variation in local pressure because cellular membranes are not rigid. Unlike microbeads, cells deform under pressure or even lyse. In isolating or enriching cells by mechanical filtration, pressure-induced lysis is exacerbated when high local fluidic velocity is present or when a filter reaches its intended capacity. Microfabrication offers new possibilities to design fluidic environments to reduce cellular stress during the filtration process. We describe the underlying biophysics of cellular stress and general solutions to scale up filtration processes for biological cells.

Graphical abstract: Deformability considerations in filtration of biological cells

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Article information


Submitted
27 Oct 2009
Accepted
16 Dec 2009
First published
19 Jan 2010

Lab Chip, 2010,10, 837-842
Article type
Paper

Deformability considerations in filtration of biological cells

J. S. Kuo, Y. Zhao, P. G. Schiro, L. Ng, D. S. W. Lim, J. P. Shelby and D. T. Chiu, Lab Chip, 2010, 10, 837
DOI: 10.1039/B922301K

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