Jump to main content
Jump to site search

Issue 7, 2010
Previous Article Next Article

High-throughput automated droplet microfluidic system for screening of reaction conditions

Author affiliations

Abstract

We demonstrate a new droplet on demand (DOD) technique and an integrated system for scanning of arbitrary combinations of 3 miscible solutions in ∼1.5 μL droplets at 3 Hz. The DOD system uses standard electromagnetic valves that are external to the microfluidic chip. This feature makes up for modularity, simplicity of assembly and compatibility with virtually any microfluidic chip and yields an on-chip footprint of less than 1 mm2. A novel protocol for formation of DOD enables generation of an arbitrarily large range of volumes of droplets at a maximum operational frequency of ∼30 Hz. The integrated system that we demonstrate can be used to scan up to 10 000 conditions of chemical and biochemical reactions per hour using ∼10 mL of solutions in total.

Graphical abstract: High-throughput automated droplet microfluidic system for screening of reaction conditions

Back to tab navigation

Supplementary files

Article information


Submitted
03 Dec 2009
Accepted
27 Jan 2010
First published
16 Feb 2010

Lab Chip, 2010,10, 816-818
Article type
Communication

High-throughput automated droplet microfluidic system for screening of reaction conditions

K. Churski, P. Korczyk and P. Garstecki, Lab Chip, 2010, 10, 816
DOI: 10.1039/B925500A

Social activity

Search articles by author

Spotlight

Advertisements