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Issue 10, 2010
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An automated two-phase microfluidic system for kinetic analyses and the screening of compound libraries

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Abstract

Droplet-based microfluidic systems allow biological and chemical reactions to be performed on a drastically decreased scale. However, interfacing the outside world with such systems and generating high numbers of microdroplets of distinct chemical composition remain challenging. We describe here an automated system in which arrays of chemically distinct plugs are generated from microtiter plates. Each array can be split into multiple small-volume copies, thus allowing several screens of the same library. The system is fully compatible with further on-chip manipulation(s) and allows monitoring of individual plugs over time (e.g. for recording reaction kinetics). Hence the technology eliminates several bottlenecks of current droplet-based microfluidic systems and should open the way for (bio-)chemical and cell-based screens.

Graphical abstract: An automated two-phase microfluidic system for kinetic analyses and the screening of compound libraries

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Publication details

The article was received on 19 Oct 2009, accepted on 04 Feb 2010 and first published on 03 Mar 2010


Article type: Paper
DOI: 10.1039/B921754A
Lab Chip, 2010,10, 1302-1307

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    An automated two-phase microfluidic system for kinetic analyses and the screening of compound libraries

    J. Clausell-Tormos, A. D. Griffiths and C. A. Merten, Lab Chip, 2010, 10, 1302
    DOI: 10.1039/B921754A

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