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Issue 42, 2010
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Sol–gel selection of hybrid G-quadruplex architectures from dynamic supramolecular guanosine libraries

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Abstract

We report an original strategy to transcribe and to fix the self-assembly of G-quadruplex architectures in self-organized nanohybrids. In the first resolution step the G-quartet is pre-amplified in solution in the presence of metal cations from a dynamic pool of ribbon-type or cyclic supramolecular architectures. Then in a second selection sol–gel step the G-quadruplex is irreversibly fixed in a siloxane inorganic network. The interface between the guanosine moiety and the heterosiloxane 3 is based on a double reversible covalent iminoboronate connection. This contributes to the high levels of adaptability and correlation in the self-organization of the supramolecular G-quadruplex and the inorganic siloxane systems. Biomimetic-type hybrids can be generated by using this strategy.

Graphical abstract: Sol–gel selection of hybrid G-quadruplex architectures from dynamic supramolecular guanosine libraries

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Supplementary files

Article information


Submitted
28 Apr 2010
Accepted
02 Jul 2010
First published
27 Aug 2010

J. Mater. Chem., 2010,20, 9443-9448
Article type
Paper

Sol–gel selection of hybrid G-quadruplex architectures from dynamic supramolecular guanosine libraries

S. Mihai, Y. Le Duc, D. Cot and M. Barboiu, J. Mater. Chem., 2010, 20, 9443
DOI: 10.1039/C0JM01248C

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