Jump to main content
Jump to site search

Issue 29, 2010
Previous Article Next Article

Tri-functionalization of mesoporous silicananoparticles for comprehensive cancer theranostics—the trio of imaging, targeting and therapy

Author affiliations

Abstract

In this work we report the development of the tri-functionalized mesoporous silica nanoparticles (MSNs) for use as theranostic compounds that orchestrate the trio of imaging, target and therapy in a single particle. The MSNs are functionalized in sequence with (1) contrast agents that enable traceable imaging of particle targeting, (2) drug payloads for therapeutic intervention and, (3) biomolecular ligands for highly-targeted particle delivery. Traceable imaging of nanoparticles was accomplished by directly incorporating a near-infrared (NIR) fluorescent contrast agent, ATTO647N, into the silica framework of MSNs, to exploit the relative transparency of most tissues at NIR wavelengths and maximize MSN surface area available for the subsequent conjugating drugs and targeting ligands. An oxygen-sensing, palladium-porphyrin based photosensitizer (Pd-porphyrin; PdTPP) was incorporated into the MSN's nanochannels, to enable photodynamic therapy (PDT). cRGDyK peptides, tiling the outermost surfaces of MSNs, were used for targeting the overexpressed αvβ3 integrins of cancer cells, and to ensure the internalization of the photosensitizer PdTPP. In vitro cell evaluation of the theranostic platform demonstrated not only excellent targeting specificity and minimal collateral damage, but highly potent therapeutic effect as well.

Graphical abstract: Tri-functionalization of mesoporous silica nanoparticles for comprehensive cancer theranostics—the trio of imaging, targeting and therapy

Back to tab navigation

Supplementary files

Article information


Submitted
09 Mar 2010
Accepted
06 May 2010
First published
22 Jun 2010

J. Mater. Chem., 2010,20, 6149-6157
Article type
Paper

Tri-functionalization of mesoporous silica nanoparticles for comprehensive cancer theranostics—the trio of imaging, targeting and therapy

S. Cheng, C. Lee, M. Chen, J. S. Souris, F. Tseng, C. Yang, C. Mou, C. Chen and L. Lo, J. Mater. Chem., 2010, 20, 6149
DOI: 10.1039/C0JM00645A

Search articles by author

Spotlight

Advertisements