Jump to main content
Jump to site search

Issue 48, 2010
Previous Article Next Article

Polymeric entrapped thiol-coated goldnanorods: cytotoxicity and suitability as molecular optoacoustic contrast agent

Author affiliations

Abstract

The behaviour of polymeric entrapped thiol-coated GNRs in culture medium under biological conditions was analysed. The in vitro cytotoxicity was studied by a Colony Forming Efficiency assay on immortalized mouse fibroblasts (Balb/3T3) obtaining a dose–effect relationship in which a half inhibitory concentration (IC50) was 20.3μM. The suitability of the new nanomaterial as an optoacoustic contrast agent was investigated in phantom studies using a hardware platform suitable for retrieving clinically relevant data. Spherical alginate phantoms containing GNR-2-PNPs at different concentrations were synthesized and the optoacoustic signal amplitudes were measured as a function of concentration. Signals could be obtained with satisfying signal-to-noise ratio (SNR) down to concentrations of 11 μM corresponding to subtoxic concentration in our in vitro model. The nanomaterial proved to be a suitable and promising contrast agent for different optoacoustic imaging modalities including multispectral approaches.

Graphical abstract: Polymeric entrapped thiol-coated gold nanorods: cytotoxicity and suitability as molecular optoacoustic contrast agent

Back to tab navigation

Article information


Submitted
09 Jul 2010
Accepted
08 Sep 2010
First published
18 Oct 2010

J. Mater. Chem., 2010,20, 10908-10914
Article type
Paper

Polymeric entrapped thiol-coated gold nanorods: cytotoxicity and suitability as molecular optoacoustic contrast agent

M. Comes Franchini, J. Ponti, R. Lemor, M. Fournelle, F. Broggi and E. Locatelli, J. Mater. Chem., 2010, 20, 10908
DOI: 10.1039/C0JM02209H

Search articles by author

Spotlight

Advertisements