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Issue 1, 2010
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In silico evolutionary dynamics of tumour virotherapy

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Replication-competent viruses based on the Edmonston vaccine strain of measles virus (MV-Edm) have potent and selective activities against various types of tumours in vitro but the responses in vivo are more variable. Some tumours are eliminated consistently while others persist despite evidence of ongoing viral propagation. In order to understand these disparate results, we have developed a model for the spatial growth of a tumour population followed by infection with a replicating virus that can spread by cell-to-cell fusion ultimately leading to cell death. We utilize the model to explore both the impact of tumour architecture and the dynamics of tumour cell-virus interactions on the outcome of therapy.

Graphical abstract: In silico evolutionary dynamics of tumour virotherapy

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Publication details

The article was received on 26 Aug 2009, accepted on 29 Sep 2009 and first published on 14 Oct 2009

Article type: Paper
DOI: 10.1039/B917597K
Integr. Biol., 2010,2, 41-45

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