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Issue 3, 2010
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Antimicrobial and antibiofilm activities of 1-alkylquinolinium bromide ionic liquids

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Abstract

Quinoline derivatives are known to possess a range of bioactive and medicinal activities, which have been exploited in the design of antibacterial, antifungal and antimalarial compounds. In this study, we report on the microbiological toxicity of a series of 1-alkylquinolinium bromides against a range of clinically relevant microorganisms, in both planktonic and sessile (biofilm) cultures. A comparison of antimicrobial activity against planktonic bacteria and established biofilms is presented. In general, 1-alkylquinolinium ionic liquids possess excellent, broad spectrum antimicrobial activity against microorganisms grown in both the planktonic and sessile, or biofilm, mode of growth. Importantly, these compounds are potent against Gram positive and Gram negative bacteria, as well as fungi, with a clear dependency on length of the alkyl substituent for activity, with compounds containing twelve and fourteen carbons in the alkyl group exhibiting highest antimicrobial and antibiofilm activity.

Graphical abstract: Antimicrobial and antibiofilm activities of 1-alkylquinolinium bromide ionic liquids

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Publication details

The article was received on 24 Sep 2009, accepted on 07 Dec 2009 and first published on 26 Jan 2010


Article type: Paper
DOI: 10.1039/B919872E
Green Chem., 2010,12, 420-425

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    Antimicrobial and antibiofilm activities of 1-alkylquinolinium bromide ionic liquids

    A. Busetti, D. E. Crawford, M. J. Earle, M. A. Gilea, B. F. Gilmore, S. P. Gorman, G. Laverty, A. F. Lowry, M. McLaughlin and K. R. Seddon, Green Chem., 2010, 12, 420
    DOI: 10.1039/B919872E

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