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Issue 22, 2010
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Anticancer activity of opened arene ruthenium metalla-assemblies

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Abstract

Cationic tetranuclear and hexanuclear opened metalla-assemblies incorporating 5,15-bis(4-pyridyl)-10,20-diphenylporphyrin (bpp) or 5,10,15-tris(4-pyridyl)-20-phenylporphyrin (tpp) panels and dinuclear arene ruthenium clips [(p-cymene)2Ru2(OOOO)2]2+ (OOOO = oxalato, 2,5-dioxydo-1,4-benzoquinonato (dobq)) have been assembled in the presence of silver triflate. All complexes were characterised by NMR, IR and UV-visible spectroscopy and electrospray ionisation mass spectrometry. The cytotoxicities of the tetranuclear and hexanuclear ruthenium complexes have been established on ovarian A2780 and A2780cisR cancer cell lines. The compounds are quite cytotoxic, the most active metalla-assembly being [Ru6(p-cymene)6(dobq)3(tpp)2]6+, with IC50 values of 2.1 μM and 3.8 μM against A2780 and A2780cisR cells, respectively.

Graphical abstract: Anticancer activity of opened arene ruthenium metalla-assemblies

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Publication details

The article was received on 25 Jan 2010, accepted on 13 Apr 2010 and first published on 04 May 2010


Article type: Paper
DOI: 10.1039/C001521K
Dalton Trans., 2010,39, 5272-5277

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    Anticancer activity of opened arene ruthenium metalla-assemblies

    N. P. E. Barry, O. Zava, J. Furrer, P. J. Dyson and B. Therrien, Dalton Trans., 2010, 39, 5272
    DOI: 10.1039/C001521K

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