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Issue 11, 2010
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Issues surrounding standard cytotoxicity testing for assessing activity of non-covalent DNA-binding metallo-drugs

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Abstract

Investigating the methods commonly used to evaluate in vitro cytotoxicity of novel compounds, specifically non-covalent DNA binders, identifies that these methods may not be appropriate. The level of anticancer activity depends not only on the incubation time but also on the absolute amount (number of moles) of drug compound applied, rather than the concentration.

Graphical abstract: Issues surrounding standard cytotoxicity testing for assessing activity of non-covalent DNA-binding metallo-drugs

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Supplementary files

Article information


Submitted
22 Dec 2009
Accepted
26 Jan 2010
First published
05 Feb 2010

Dalton Trans., 2010,39, 2772-2774
Article type
Communication

Issues surrounding standard cytotoxicity testing for assessing activity of non-covalent DNA-binding metallo-drugs

Alexandra. J. Pope, C. Bruce, B. Kysela and Michael. J. Hannon, Dalton Trans., 2010, 39, 2772
DOI: 10.1039/B927129P

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