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Issue 11, 2010
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Issues surrounding standard cytotoxicity testing for assessing activity of non-covalent DNA-binding metallo-drugs

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Abstract

Investigating the methods commonly used to evaluate in vitro cytotoxicity of novel compounds, specifically non-covalent DNA binders, identifies that these methods may not be appropriate. The level of anticancer activity depends not only on the incubation time but also on the absolute amount (number of moles) of drug compound applied, rather than the concentration.

Graphical abstract: Issues surrounding standard cytotoxicity testing for assessing activity of non-covalent DNA-binding metallo-drugs

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Publication details

The article was received on 22 Dec 2009, accepted on 26 Jan 2010 and first published on 05 Feb 2010


Article type: Communication
DOI: 10.1039/B927129P
Dalton Trans., 2010,39, 2772-2774

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    Issues surrounding standard cytotoxicity testing for assessing activity of non-covalent DNA-binding metallo-drugs

    Alexandra. J. Pope, C. Bruce, B. Kysela and Michael. J. Hannon, Dalton Trans., 2010, 39, 2772
    DOI: 10.1039/B927129P

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