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Issue 11, 2010
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Anticancer activity of osmium metalla-rectangles

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Abstract

A series of cationic metalla-rectangles of the general formula [(p-cymene)4Os4(OOOO)2(NN)2]4+ have been obtained in methanol from the dinuclear arene osmium precursors [(p-cymene)2Os2(OOOO)2Cl2] (OOOO = 2,5-dioxydo-1,4-benzoquinonato (dhbq), 2,5-dichloro-1,4-benzoquinonato (dcbq)) by reaction with bipyridine linkers (NN = 4,4′-bipyridine, 1,2-bis(4-pyridyl)ethylene) in the presence of AgCF3SO3. All complexes were isolated as triflate salts and characterised by NMR, IR and UV-visible spectroscopy. The cytotoxicities of the dinuclear and tetranuclear osmium complexes were established using ovarian A2780 cancer cell lines. The most active metalla-rectangle, [(p-cymene)4Os4(dhbq)2(4,4′-bipyridine)2]4+, shows an IC50 value of 5.7 μM (comparable to cisplatin) against A2780 cancer cells and 7.5 μM against the cisplatin resistant A2780cisR cells.

Graphical abstract: Anticancer activity of osmium metalla-rectangles

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Publication details

The article was received on 27 Nov 2009, accepted on 06 Jan 2010 and first published on 04 Feb 2010


Article type: Paper
DOI: 10.1039/B925015H
Dalton Trans., 2010,39, 2816-2820

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    Anticancer activity of osmium metalla-rectangles

    N. P. E. Barry, F. Edafe, P. J. Dyson and B. Therrien, Dalton Trans., 2010, 39, 2816
    DOI: 10.1039/B925015H

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