Jump to main content
Jump to site search

Issue 35, 2010
Previous Article Next Article

The status of platinum anticancer drugs in the clinic and in clinical trials

Author affiliations

Abstract

Since its approval in 1979 cisplatin has become an important component in chemotherapy regimes for the treatment of ovarian, testicular, lung and bladder cancers, as well as lymphomas, myelomas and melanoma. Unfortunately its continued use is greatly limited by severe dose limiting side effects and intrinsic or acquired drug resistance. Over the last 30 years, 23 other platinum-based drugs have entered clinical trials with only two (carboplatin and oxaliplatin) of these gaining international marketing approval, and another three (nedaplatin, lobaplatin and heptaplatin) gaining approval in individual nations. During this time there have been more failures than successes with the development of 14 drugs being halted during clinical trials. Currently there are four drugs in the various phases of clinical trial (satraplatin, picoplatin, Lipoplatin™ and ProLindac™). No new small molecule platinum drug has entered clinical trials since 1999 which is representative of a shift in focus away from drug design and towards drug delivery in the last decade. In this perspective article we update the status of platinum anticancer drugs currently approved for use, those undergoing clinical trials and those discontinued during clinical trials, and discuss the results in the context of where we believe the field will develop over the next decade.

Graphical abstract: The status of platinum anticancer drugs in the clinic and in clinical trials

Back to tab navigation

Article information


Submitted
12 Apr 2010
Accepted
08 May 2010
First published
30 Jun 2010

Dalton Trans., 2010,39, 8113-8127
Article type
Perspective

The status of platinum anticancer drugs in the clinic and in clinical trials

N. J. Wheate, S. Walker, G. E. Craig and R. Oun, Dalton Trans., 2010, 39, 8113
DOI: 10.1039/C0DT00292E

Social activity

Search articles by author

Spotlight

Advertisements