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Issue 5, 2010
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Exploring the cellular accumulation of metal complexes

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Abstract

Transition metal complexes offer great potential as diagnostic and therapeutic agents, and a growing number of biological applications have been explored. To be effective, these complexes must reach their intended target inside the cell. Here we review the cellular accumulation of metal complexes, including their uptake, localization, and efflux. Metal complexes are taken up inside cells through various mechanisms, including passive diffusion and entry through organic and metal transporters. Emphasis is placed on the methods used to examine cellular accumulation, to identify the mechanism(s) of uptake, and to monitor possible efflux. Conjugation strategies that have been employed to improve the cellular uptake characteristics of metal complexes are also described.

Graphical abstract: Exploring the cellular accumulation of metal complexes

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Article information


Submitted
23 Oct 2009
Accepted
11 Nov 2009
First published
23 Dec 2009

Dalton Trans., 2010,39, 1159-1170
Article type
Perspective

Exploring the cellular accumulation of metal complexes

C. A. Puckett, R. J. Ernst and J. K. Barton, Dalton Trans., 2010, 39, 1159
DOI: 10.1039/B922209J

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