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Issue 3, 2010
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Metal chelating systems synthesized using the copper(i) catalyzed azide-alkynecycloaddition

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The copper(I) catalyzed azide-alkyne cycloaddition (CuAAC) is the premier example of a click reaction. The reaction is modular, reliable and easy to perform, providing easy access to molecular diversity. The majority of reported applications of the reaction employ the 1,2,3-triazole as a stable linkage to connect two chemical/biological components, while the potential for metal coordination of the heterocycle itself has received much less attention. In fact, 1,4-functionalized 1,2,3-triazoles are versatile ligands offering several donor sites for metal coordination, including N3, N2 and C5. In this article, we summarize the areas in which the CuAAC has been applied to the synthesis of novel triazole-containing ligands for transition metals.

Graphical abstract: Metal chelating systems synthesized using the copper(i) catalyzed azide-alkyne cycloaddition

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Article information

01 Jul 2009
16 Oct 2009
First published
23 Nov 2009

Dalton Trans., 2010,39, 675-696
Article type

Metal chelating systems synthesized using the copper(I) catalyzed azide-alkyne cycloaddition

H. Struthers, T. L. Mindt and R. Schibli, Dalton Trans., 2010, 39, 675
DOI: 10.1039/B912608B

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