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Issue 4, 2010
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Click chemistry with DNA

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The advent of click chemistry has led to an influx of new ideas in the nucleic acids field. The copper catalysed alkyneazide cycloaddition (CuAAC) reaction is the method of choice for DNA click chemistry due to its remarkable efficiency. It has been used to label oligonucleotides with fluorescent dyes, sugars, peptides and other reporter groups, to cyclise DNA, to synthesise DNA catenanes, to join oligonucleotides to PNA, and to produce analogues of DNA with modified nucleobases and backbones. In this critical review we describe some of the pioneering work that has been carried out in this area (78 references).

Graphical abstract: Click chemistry with DNA

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The article was received on 01 Sep 2009 and first published on 09 Feb 2010

Article type: Critical Review
DOI: 10.1039/B901971P
Chem. Soc. Rev., 2010,39, 1388-1405

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    Click chemistry with DNA

    A. H. El-Sagheer and T. Brown, Chem. Soc. Rev., 2010, 39, 1388
    DOI: 10.1039/B901971P

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