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Issue 8, 2010
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Designer self-assembling peptide nanofiber biological materials

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Abstract

Scientists and bioengineers have dreamed of designing materials from the bottom up with the finest detail and ultimate control at the single molecular level. The discovery of a class of self-assembling peptides that spontaneously undergo self-organization into well-ordered structures opened a new avenue for molecular fabrication of biological materials. Since this discovery, diverse classes of short peptides have been invented with broad applications, including 3D tissue cell culture, reparative and regenerative medicine, tissue engineering, slow drug release and medical device development. Molecular design of new materials using short peptides is poised to become increasingly important in biomedical research, biomedical technology and medicine, and is covered in this tutorial review.

Graphical abstract: Designer self-assembling peptide nanofiber biological materials

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Article information


Submitted
22 Oct 2009
Accepted
15 Mar 2010
First published
03 Jun 2010

Chem. Soc. Rev., 2010,39, 2780-2790
Article type
Tutorial Review

Designer self-assembling peptide nanofiber biological materials

C. A. E. Hauser and S. Zhang, Chem. Soc. Rev., 2010, 39, 2780
DOI: 10.1039/B921448H

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