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Issue 2, 2010
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Fluorine & chirality: how to create a nonracemic stereogenic carbonfluorine centre?

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Abstract

Enantiopure organofluorine compounds are at the forefront of innovation in the field of fluorine chemistry. The significant progress in modern fluoroorganic chemistry parallels the tremendous achievements in organocatalysis and organometallic catalysis that have permitted the asymmetric synthesis of chiral chemicals featuring a fluorinated stereogenic carbon centre. This tutorial review provides an overview of the current state of the art in asymmetric construction of stereogenic carbonfluorine centres, not only by direct fluorination, but also by asymmetric reaction of fluorinated substrates.

Graphical abstract: Fluorine & chirality: how to create a nonracemic stereogenic carbon–fluorine centre?

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Publication details

The article was received on 07 Jul 2009 and first published on 16 Oct 2009


Article type: Tutorial Review
DOI: 10.1039/B909566G
Chem. Soc. Rev., 2010,39, 558-568

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    Fluorine & chirality: how to create a nonracemic stereogenic carbonfluorine centre?

    D. Cahard, X. Xu, S. Couve-Bonnaire and X. Pannecoucke, Chem. Soc. Rev., 2010, 39, 558
    DOI: 10.1039/B909566G

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