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Issue 3, 2010
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Engineered voltage-responsive nanopores

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Abstract

The creation of synthetic devices that mimic functionality of biological systems is a task of fundamental importance for the future development of bio- and nanotechnology and also an ultimate test of our understanding of the biological systems. Among a plethora of bio-inspired devices, designed nanopores and nanochannels with an embedded functionality are of particular interest because of their potential applications in nanofluidic electronics, biosensing, separation, synthetic biology, and single-molecule manipulation. In this respect, nanopores with built-in stimulus-responsive properties are of special benefit. A transmembrane potential is a particularly useful stimulus as it is non-invasive, tunable, and can act over a short time scale. This critical review considers engineered solid-state and protein nanopores with voltage-responsive properties. The engineered systems show nonlinear current–voltage curves, and/or voltage-dependent switching between discrete conductance states (141 references).

Graphical abstract: Engineered voltage-responsive nanopores

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Submitted
10 Jun 2009
First published
04 Dec 2009

Chem. Soc. Rev., 2010,39, 1115-1132
Article type
Critical Review

Engineered voltage-responsive nanopores

Z. S. Siwy and S. Howorka, Chem. Soc. Rev., 2010, 39, 1115 DOI: 10.1039/B909105J

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