Jump to main content
Jump to site search

Issue 3, 2010
Previous Article Next Article

Engineered voltage-responsive nanopores

Author affiliations


The creation of synthetic devices that mimic functionality of biological systems is a task of fundamental importance for the future development of bio- and nanotechnology and also an ultimate test of our understanding of the biological systems. Among a plethora of bio-inspired devices, designed nanopores and nanochannels with an embedded functionality are of particular interest because of their potential applications in nanofluidic electronics, biosensing, separation, synthetic biology, and single-molecule manipulation. In this respect, nanopores with built-in stimulus-responsive properties are of special benefit. A transmembrane potential is a particularly useful stimulus as it is non-invasive, tunable, and can act over a short time scale. This critical review considers engineered solid-state and protein nanopores with voltage-responsive properties. The engineered systems show nonlinear current–voltage curves, and/or voltage-dependent switching between discrete conductance states (141 references).

Graphical abstract: Engineered voltage-responsive nanopores

Back to tab navigation

Additions and corrections

Article information

10 Jun 2009
First published
04 Dec 2009

Chem. Soc. Rev., 2010,39, 1115-1132
Article type
Critical Review

Engineered voltage-responsive nanopores

Z. S. Siwy and S. Howorka, Chem. Soc. Rev., 2010, 39, 1115 DOI: 10.1039/B909105J

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Search articles by author