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Issue 2, 2010
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Intermolecular oxidative cross-coupling of arenes

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Biaryls constitute an important subunit found in medicinal agents, functional materials, and natural products. While the Suzuki reaction and related processes currently represent the method of choice for the construction of arenearene bonds, the direct-coupling of two unfunctionalized arenes mediated by the addition of an oxidant represents a powerful alternative strategy for biaryl synthesis. This tutorial review describes recent progress in this rapidly developing field, focusing on intermolecular examples of selective arene oxidation strategies and metal-catalyzed oxidative cross-coupling via C–H activation.

Graphical abstract: Intermolecular oxidative cross-coupling of arenes

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Article information

16 Jun 2009
First published
07 Oct 2009

Chem. Soc. Rev., 2010,39, 540-548
Article type
Tutorial Review

Intermolecular oxidative cross-coupling of arenes

J. A. Ashenhurst, Chem. Soc. Rev., 2010, 39, 540
DOI: 10.1039/B907809F

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