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Issue 4, 2010
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Marrying click chemistry with polymerization: expanding the scope of polymeric materials

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Abstract

Click chemistry constitutes a class of reactions broadly characterized by efficiency, selectivity, and tolerance to a variety of solvents and functional groups. By far the most widely utilized of these efficient transformation reactions is the CuI-catalyzed azidealkyne cycloaddition. This reaction has been creatively employed to facilitate the preparation of complex macromolecules, such as multiblock copolymers, shell or core cross-linked micelles, and dendrimers. This critical review highlights the application of click chemistry, in particular the CuI-catalyzed azide-alkyne cycloaddition, to the synthesis of a wide variety of new materials with possible uses as drug delivery agents, tissue engineering scaffolds, and dispersible nanomaterials (83 references).

Graphical abstract: Marrying click chemistry with polymerization: expanding the scope of polymeric materials

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Publication details

The article was received on 26 Aug 2009 and first published on 03 Nov 2009


Article type: Critical Review
DOI: 10.1039/B901978M
Chem. Soc. Rev., 2010,39, 1338-1354

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    Marrying click chemistry with polymerization: expanding the scope of polymeric materials

    P. L. Golas and K. Matyjaszewski, Chem. Soc. Rev., 2010, 39, 1338
    DOI: 10.1039/B901978M

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