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Issue 8, 2010
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In search of pure liquid salt forms of aspirin: ionic liquid approaches with acetylsalicylic acid and salicylic acid

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Abstract

We present an ionic liquid (IL) approach towards a dual functional liquid salt form of aspirin using different pharmaceutically active cations composed of antibacterials, analgesics, local anesthetics, and antiarrhythmic drugs in combination with acetylsalicylic acid or its metabolite salicylic acid and discuss stability of these ILs in comparison to solid salts. Several low-melting or liquid salts of salicylic acid with dual functionality and promising properties were isolated and characterized; however, although such ILs with aspirin could be prepared, they suffer from limited stability and slowly decompose into the corresponding salicylate ILs when exposed to moisture.

Graphical abstract: In search of pure liquid salt forms of aspirin: ionic liquid approaches with acetylsalicylic acid and salicylic acid

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Submitted
12 Nov 2009
Accepted
18 Jan 2010
First published
22 Jan 2010

Phys. Chem. Chem. Phys., 2010,12, 2011-2017
Article type
Paper

In search of pure liquid salt forms of aspirin: ionic liquid approaches with acetylsalicylic acid and salicylic acid

K. Bica, C. Rijksen, M. Nieuwenhuyzen and R. D. Rogers, Phys. Chem. Chem. Phys., 2010, 12, 2011
DOI: 10.1039/B923855G

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