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Issue 41, 2010
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Ligand dimerization programmed by hybridization to study multimeric ligand–receptor interactions

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Abstract

Oligomerization of receptors induced or stabilized by polyvalent ligands is a fundamental mechanism in cellular recognition and signal transduction. Herein we report a general approach to encode complex peptide macrocycles with peptide nucleic acid (PNA) tags and program their oligomerization through hybridization as exemplified with a ligand binding to oligomeric DR5, a receptor of TRAIL cytokine.

Graphical abstract: Ligand dimerization programmed by hybridization to study multimeric ligand–receptor interactions

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Article information


Submitted
28 Jul 2010
Accepted
23 Aug 2010
First published
20 Sep 2010

Chem. Commun., 2010,46, 7742-7744
Article type
Communication

Ligand dimerization programmed by hybridization to study multimeric ligand–receptor interactions

K. Gorska, J. Beyrath, S. Fournel, G. Guichard and N. Winssinger, Chem. Commun., 2010, 46, 7742
DOI: 10.1039/C0CC02852E

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