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Issue 42, 2010
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Simultaneous iridium catalysed oxidation and enzymatic reduction employing orthogonal reagents

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Abstract

An iridium catalysed oxidation was coupled concurrently to an asymmetric biocatalytic reduction in one-pot; thus it was shown for the first time that iridium- and alcohol dehydrogenase-catalysed redox reactions are compatible. As a model system racemic chlorohydrins were transformed to enantioenriched chlorohydrins via an oxidation–asymmetric reduction sequence.

Graphical abstract: Simultaneous iridium catalysed oxidation and enzymatic reduction employing orthogonal reagents

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Supplementary files

Article information


Submitted
26 Jul 2010
Accepted
07 Sep 2010
First published
27 Sep 2010

Chem. Commun., 2010,46, 8046-8048
Article type
Communication

Simultaneous iridium catalysed oxidation and enzymatic reduction employing orthogonal reagents

F. G. Mutti, A. Orthaber, J. H. Schrittwieser, J. G. D. Vries, R. Pietschnig and W. Kroutil, Chem. Commun., 2010, 46, 8046
DOI: 10.1039/C0CC02813D

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