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Issue 1, 2011
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Synthesis of phosphonamidate peptides by Staudinger reactions of silylated phosphinic acids and esters§

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Abstract

The Staudinger reaction of unprotected azido-peptides with silylated phosphinic acids and esters on the solid support offers a straightforward acid-free entry to different phosphonamidate peptide esters or acids under mild conditions in high purity and yield.

Graphical abstract: Synthesis of phosphonamidate peptides by Staudinger reactions of silylated phosphinic acids and esters

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Article information


Submitted
09 Jul 2010
Accepted
06 Aug 2010
First published
07 Sep 2010

Chem. Commun., 2011,47, 349-351
Article type
Communication

Synthesis of phosphonamidate peptides by Staudinger reactions of silylated phosphinic acids and esters

I. Wilkening, G. D. Signore and C. P. R. Hackenberger, Chem. Commun., 2011, 47, 349
DOI: 10.1039/C0CC02472D

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