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Issue 29, 2010
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Discovery of potent inhibitor for farnesyl pyrophosphate synthase in the mevalonate pathway

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Abstract

The mevalonate pathway is an important drug target for the treatment of cancer and cardiovascular disease. We synthesized and studied a new type of nitrogen-containing bisphosphonate analogs and developed a sensitive end point assay method for enzyme FPPS, which was used for inhibitor screening. One potent FPPS inhibitor was discovered, and the structure–activity relationship of bisphosphonates for the enzyme inactivation was studied.

Graphical abstract: Discovery of potent inhibitor for farnesyl pyrophosphate synthase in the mevalonate pathway

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Submitted
17 Apr 2010
Accepted
20 May 2010
First published
14 Jun 2010

Chem. Commun., 2010,46, 5340-5342
Article type
Communication

Discovery of potent inhibitor for farnesyl pyrophosphate synthase in the mevalonate pathway

J. Gao, X. Chu, Y. Qiu, L. Wu, Y. Qiao, J. Wu and D. Li, Chem. Commun., 2010, 46, 5340
DOI: 10.1039/C0CC00992J

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