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Issue 31, 2010
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Anionic phthalocyanines targeting G-quadruplexes and inhibiting telomerase activity in the presence of excessive DNA duplexes

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Abstract

Anionic phthalocyanines inhibited efficiently telomerase activity even in the presence of excess double-stranded DNA (dsDNA) because of their selective binding to telomere G-quadruplex, although low selectivity of a typical cationic ligand, TMPyP4, to the G-quadruplex allowed telomerase reaction under conditions with dsDNA.

Graphical abstract: Anionic phthalocyanines targeting G-quadruplexes and inhibiting telomerase activity in the presence of excessive DNA duplexes

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Publication details

The article was received on 15 Apr 2010, accepted on 16 Jun 2010 and first published on 01 Jul 2010


Article type: Communication
DOI: 10.1039/C0CC00956C
Chem. Commun., 2010,46, 5740-5742

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    Anionic phthalocyanines targeting G-quadruplexes and inhibiting telomerase activity in the presence of excessive DNA duplexes

    H. Yaku, T. Murashima, D. Miyoshi and N. Sugimoto, Chem. Commun., 2010, 46, 5740
    DOI: 10.1039/C0CC00956C

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