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Issue 32, 2010
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An ultrahighly sensitive and selective electrochemical DNA sensor via nicking endonuclease assisted current change amplification

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Abstract

Based on the “nicking endonuclease assisted” detection strategy, a novel electrochemical biosensor for the sequence-specific detection of DNA with ultrahigh sensitivity and selectivity is developed. By employing the above strategy, this DNA biosensor can detect as low as 0.068 fM target DNA and exhibits high discrimination ability even against a single-base mismatch.

Graphical abstract: An ultrahighly sensitive and selective electrochemical DNA sensor via nicking endonuclease assisted current change amplification

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Article information


Submitted
03 Apr 2010
Accepted
01 Jun 2010
First published
02 Jul 2010

Chem. Commun., 2010,46, 5939-5941
Article type
Communication

An ultrahighly sensitive and selective electrochemical DNA sensor via nicking endonuclease assisted current change amplification

J. Chen, J. Zhang, J. Li, F. Fu, H. Yang and G. Chen, Chem. Commun., 2010, 46, 5939
DOI: 10.1039/C0CC00748J

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