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Issue 30, 2010
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Chemoenzymatic asymmetric total synthesis of (S)-Rivastigmine using ω-transaminases

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Abstract

A straightforward, high-yielding, chemoenzymatic total synthesis of enantiopure (S)-Rivastigmine was developed using various ω-transaminases for the asymmetric amination of appropriate acetophenone precursors. Optimisation of the biotransformation allowed scale-up and the total synthesis of (S)-Rivastigmine.

Graphical abstract: Chemoenzymatic asymmetric total synthesis of (S)-Rivastigmine using ω-transaminases

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Article information


Submitted
25 Mar 2010
Accepted
26 Apr 2010
First published
11 May 2010

Chem. Commun., 2010,46, 5500-5502
Article type
Communication

Chemoenzymatic asymmetric total synthesis of (S)-Rivastigmine using ω-transaminases

M. Fuchs, D. Koszelewski, K. Tauber, W. Kroutil and K. Faber, Chem. Commun., 2010, 46, 5500
DOI: 10.1039/C0CC00585A

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